TABLE OF CONTENTS EXECUTIVE SUMMARY MARKET OVERVIEW MARKET DYNAMICS ONCOLOGY BIOMARKERS DIAGNOSTICS MARKET ONCOLOGY BIOMARKERS DISCOVERY MARKET GEOGRAPHICAL ANALYSIS COMPETITIVE LANDSCAPE 1 INTRODUCTION 1.1 KEY TAKE-AWAYS 1.2 REPORT DESCRIPTION 1.3 MARKETS COVERED 1.4 RESEARCH METHODOLOGY 1.5 STAKEHOLDERS 2 SUMMARY 3 MARKET OVERVIEW 3.1 INTRODUCTION 3.2 DEFINING THE MARKET 3.3 CLASSIFICATION OF CANCER BIOMARKERS 3.4 FACTORS INFLUENCING MARKET GROWTH 3.5 MARKET SHARE ANALYSIS 3.5.1 BY MARKET SEGMENT 3.5.2 BY MARKET PLAYER 3.6 PATENT ANALYSIS 4 MARKET DYNAMICS 4.1 INTRODUCTION 4.2 DRIVERS 4.2.1 ENHANCED ACCURACY & SPEED OF DIAGNOSIS 4.2.2 STREAMLINED DRUG DELIVERY PROCESS 4.2.3 INCREASED SURVIVAL RATES 4.2.4 NON-INVASIVE DIAGNOSIS 4.2.5 U.S. GOVERNMENT INITIATIVES 4.2.6 FEWER FDA APPROVALS FOR CANCER DRUGS 4.2.7 DEMOGRAPHIC & OTHER FACTORS 4.3 RESTRAINTS 4.3.1 HIGH COST & COMPLEXITY OF BIOMARKER VALIDATION 4.3.2 REIMBURSEMENT ISSUES 4.3.3 OTHER VALIDATION ISSUES 4.3.4 NEED FOR IMMEDIATE PROCESSING 5 ONCOLOGY BIOMARKERS DIAGNOSTICS MARKET 5.1 INTRODUCTION 5.2 IMMUNOASSAYS 5.3 IMMUNOHISTOCHEMICAL (IHC) TESTS 5.4 MOLECULAR (DNA AND GENOMIC) DIAGNOSTIC ASSAYS 5.5 GENETIC AND GENOMIC MARKERS 5.6 PROTEOMICS 5.7 FLOW CYTOMETRY 5.8 STEM CELL MARKERS 5.9 MONOCLONAL ANTIBODIES 5.10 PHARMACOGENOMICS 5.11 DNA MICROARRAYS 5.12 IVD MULTIVARIATE INDEX ASSAYS (IVDMIA) 6 ONCOLOGY BIOMARKERS DISCOVERY MARKET 6.1 METABOLOMICS 6.2 GENETIC METHODS 6.2.1 DNA ARRAYS 6.2.2 SOUTHERN BLOT 6.2.3 POLYMERASE CHAIN REACTION (PCR) 6.2.4 REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION (RT-PCR) 6.2.5 FLUORESCENT IN SITU HYBRIDIZATION (FISH) 6.3 PROTEIN METHODS 6.3.1 IMMUNOHISTOCHEMISTRY (IHC) 6.3.2 MASS SPECTROMETRY (MS) 6.4 IMAGING 6.4.1 POSITRON EMISSION TOMOGRAPHY (PET) 6.4.2 COMPUTED TOMOGRAPHY (CT) 6.4.3 MAGNETIC RESONANCE IMAGING (MRI) 6.4.4 MAGNETIC RESONANCE SPECTROSCOPY (MRS) 6.4.5 SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) 6.4.6 X-RAY 6.4.7 BIOPHOTONICS 6.4.8 ULTRASOUND 7 GEOGRAPHICAL ANALYSIS 7.1.1 NORTH AMERICA 7.1.2 EUROPE 7.1.3 ASIA 7.1.4 ROW 8 COMPETITIVE LANDSCAPE 9 COMPANY PROFILES 9.1 ABBOTT LABORATORIES 9.2 AFFYMETRIX, INC 9.3 AGENDIA BV 9.4 AMBRILIA BIOPHARMA 9.5 ASTELLAS PHARMA US INC 9.6 AUREON LABORATORIES, INC 9.7 BECKMAN COULTER, INC 9.8 BECTON, DICKINSON AND COMPANY 9.9 BIOCUREX INC 9.10 BIOMERIEUX S.A. 9.11 BIOMODA, INC 9.12 CLARIENT, INC 9.13 CORRELOGIC SYSTEMS, INC 9.14 DIADEXUS, INC 9.15 DIAGNOCURE INC 9.16 EPIGENOMICS AG 9.17 EUSA PHARMA (USA) INC 9.18 EXACT SCIENCES CORP 9.19 FUJIREBIO DIAGNOSTICS, INC 9.20 GEN-PROBE, INC 9.21 GENOMIC HEALTH INC 9.22 GERON CORP 9.23 HOLOGIC INC 9.24 IMMUNOMEDICS, INC 9.25 INVERNESS MEDICAL INNOVATIONS, INC 9.26 LABORATORY CORP. OF AMERICA HOLDINGS 9.27 MORPHOTEK, INC 9.28 MYRIAD GENETICS, INC 9.29 NORTHWEST BIOTHERAPEUTICS INC 9.30 OCIMUM BIOSOLUTIONS LTD 9.31 ONCOTHYREON, INC 9.32 POLYMEDCO INC 9.33 PONIARD PHARMACEUTICALS INC 9.34 QIAGEN N.V. 9.35 RADIENT PHARMACEUTICALS CORP 9.36 SIEMENS HEALTHCARE 9.37 VERIDEX LLC APPENDIX U.S. PATENTS EUROPE PATENTS JAPAN PATENTS LIST OF TABLES SUMMARY TABLE GLOBAL ONCOLOGY BIOMARKER MARKET,BY SEGMENTS 2007-2014 ($MILLION) TABLE 1 LIST OF FDA APPROVED BIOMARKERS TABLE 2 FDA INITIATIVES FOR ONCOLOGY BIOMARKERS TABLE 3 GLOBAL ONCOLOGY BIOMARKER DIAGNOSTIC MARKET,BY TECHNOLOGIES 2007-2014 ($MILLION) TABLE 4 GLOBAL ONCOLOGY BIOMARKER DIAGNOSTIC MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 5 GLOBAL IMMUNOASSAYS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 6 GLOBAL IMMUNOHISTOCHEMICAL TESTS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 7 GLOBAL MOLECULAR (DNA AND GENOMIC) DIAGNOSTIC ASSAYS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 8 GLOBAL GENOMICS AND GENETIC MARKERS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 9 GLOBAL PROTEOMICS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 10 GLOBAL FLOW CYTOMETRY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 11 GLOBAL STEM CELL MARKERS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 12 GLOBAL MONOCLONAL ANTIBODIES MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 13 GLOBAL PHARMACOGENOMICS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 14 GLOBAL DNA MICROARRAYS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 15 GLOBAL IN VITRO DIAGNOSTIC MULTIVARIATE INDEX ASSAYS (IVDMIA) MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 16 GLOBAL ONCOLOGY BIOMARKER DISCOVERY MARKET, BY SEGMENTS 2007-2014 ($MILLION) TABLE 17 GLOBAL ONCOLOGY BIOMARKER DISCOVERY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 18 GLOBAL METABOLOMICS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 19 GLOBAL GENETIC METHODS MARKET, BY METHODS 2007-2014 ($MILLION) TABLE 20 GLOBAL GENETIC METHODS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 21 GLOBAL DNA ARRAYS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 22 GLOBAL SOUTHERN BLOT MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 23 GLOBAL POLYMERASE CHAIN REACTION (PCR) MARKET,BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 24 GLOBAL REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 25 GLOBAL FLUORESCENT IN SITU HYBRIDIZATION MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 26 GLOBAL PROTEIN METHODS MARKET, BY SEGMENTS 2007-2014 ($MILLION) TABLE 27 GLOBAL PROTEIN METHODS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 28 GLOBAL IMMUNOHISTOCHEMISTRY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 29 GLOBAL MASS SPECTROMETRY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 30 GLOBAL IMAGING MARKET, BY SEGMENTS 2007-2014 ($MILLION) TABLE 31 GLOBAL IMAGING MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 32 GLOBAL POSITRON EMISSION TOMOGRAPHY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 33 GLOBAL COMPUTED TOMOGRAPHY (CT) MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 34 GLOBAL MAGNETIC RESONANCE IMAGING MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 35 GLOBAL MAGNETIC RESONANCE SPECTROSCOPY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 36 GLOBAL SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 37 GLOBAL X-RAY MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 38 GLOBAL BIOPHOTONICS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 39 GLOBAL ULTRASOUND MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 40 GLOBAL ONCOLOGY BIOMARKERS MARKET, BY GEOGRAPHY 2007-2014 ($MILLION) TABLE 41 NORTH AMERICAN ONCOLOGY BIOMARKERS MARKET, BY SEGMENT 2007 – 2014 ($MILLION) TABLE 42 EUROPEAN ONCOLOGY BIOMARKERS MARKET, BY SEGMENTS 2007-2014 ($MILLION) TABLE 43 ASIAN ONCOLOGY BIOMARKERS MARKET, BY SEGMENTS 2007-2014 ($MILLION) TABLE 44 ROW ONCOLOGY BIOMARKERS MARKET, BY SEGMENTS 2007-2014 ($MILLION) TABLE 45 MERGERS AND ACQUISITIONS (2008-JANUARY 2010) TABLE 46 NEW PRODUCT LAUNCHES (2008- MARCH 2010) TABLE 47 AGREEMENTS AND COLLABORATIONS (2008- JANUARY 2010) LIST OF FIGURES FIGURE 1 ONCOLOGY BIOMARKER MARKET SEGMENTATION FIGURE 2 CLASSIFICATION OF CANCER BIOMARKERS FIGURE 3 COMPARATIVE ANALYSIS OF MARKET DRIVERS FIGURE 4 COMPARATIVE ANALYSIS OF MARKET RESTRAINTS FIGURE 5 ONCOLOGY BIOMARKER DIAGNOSTICS MARKET DYNAMICS FIGURE 6 MARKET SHARES OF MAJOR PLAYERS IN ONCOLOGY BIOMARKERS MOLECULAR DIAGNOSTICS FIGURE 7 PATENT ANALYSIS BY GEOGRAPHY (2005-2009) FIGURE 8 PATENT ANALYSIS BY COMPETITORS (2004-MARCH 2010) FIGURE 9 DRUG DEVELOPMENT PROCESS FLOW FIGURE 9 DEVELOPMENTS IN GLOBAL ONCOLOGY BIOMARKERS MARKET (2008 – MARCH 2010) FIGURE 10 KEY PLAYERS IN STRATEGIC DEVELOPMENT